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SVF for knee osteoarthritis: prospective clinical trial
Boada-Pladellorens A, Avellanet M, Veiga A, Pages-Bolibar E et al.
Biomedicines · 2021
SUMMARY
This study evaluated the efficacy and safety of a stromal vascular fraction (SVF) obtained from autologous adipose tissue in patients with symptomatic knee osteoarthritis. A total of 184 patients were included, of whom 78 completed follow-up and were analysed. Participants received an intra-articular injection of a standardised SVF product (Celstem®) and were evaluated before treatment and at 1, 6 and 12 months using pain scales (VAS), joint function (KOOS), quality of life (SF-36) and magnetic resonance imaging (MOCART). Following treatment, significant improvements were observed in pain, knee function and quality of life, with few adverse effects reported. No significant changes were detected in the overall cartilage repair score by magnetic resonance imaging.
STUDY DATA
Type of study
Clinical trial
Post
2021
Magazine
2021
PMID
41462925
DOI
10.3390/biomedicines13122913
CONCLUSION
The intra-articular infiltration of autologous SVF showed potential to reduce pain and improve function and quality of life in patients with knee osteoarthritis during a 12-month follow-up. Although the clinical results were favorable, the study did not demonstrate significant radiological changes confirming structural cartilage regeneration.
Limitations
There was no control group or placebo to compare the results with.
The study was neither randomized nor blinded.
Of the 184 patients initially included, only 78 were ultimately analyzed.
The follow-up was limited to 12 months.
No significant improvements were observed in the overall radiological parameters of cartilage repair.
The authors indicate that randomized and controlled clinical trials are necessary to confirm the observed efficacy.
The study was neither randomized nor blinded.
Of the 184 patients initially included, only 78 were ultimately analyzed.
The follow-up was limited to 12 months.
No significant improvements were observed in the overall radiological parameters of cartilage repair.
The authors indicate that randomized and controlled clinical trials are necessary to confirm the observed efficacy.
RELEVANCE TO EONLIFE
This study provides clinical evidence on the use of cellular products derived from autologous adipose tissue in patients with knee osteoarthritis. The results suggest that therapies based on SVF can contribute to pain control and functional improvement, areas closely related to regenerative medicine treatments and osteoarticular health. Furthermore, it supports the safety of this type of procedures when performed with standardized products under clinical control.
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